From benchmarking HITS-CLIP peak detection programs to a new method for identification of miRNA-binding sites from Ago2-CLIP data

Experimental evidence indicates that about 60% of miRNA-binding activity does not follow the canonical rule about the seed matching between miRNA and target mRNAs, but rather a non-canonical miRNA targeting activity outside the seed or with a seed-like motifs. Here, we propose a new unbiased method...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Bottini, Silvia, Hamouda-Tekaya, Nedra, Tanasa, Bogdan, Zaragosi, Laure-Emmanuelle, Grandjean, Valerie, Repetto, Emanuela, Trabucchi, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435922/
https://ncbi.nlm.nih.gov/pubmed/28108660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx007
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