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Genome-wide screen of gamma-secretase–mediated intramembrane cleavage of receptor tyrosine kinases
Receptor tyrosine kinases (RTKs) have been demonstrated to signal via regulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavage by gamma-secretase leads to release of a soluble intracellular receptor fragment with functional activity. For most RTKs, howe...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5662267/ https://ncbi.nlm.nih.gov/pubmed/28904208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-04-0261 |
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