TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets

Tumor-associated macrophages (TAMs) are heterogeneous and can adopt a spectrum of activation states between pro-inflammatory and pro-tumorigenic in response to the microenvironment. We have previously shown that TTI-621, a soluble SIRPαFc fusion protein that blocks the CD47 “do-not-eat” signal, prom...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lin, Gloria H. Y., Chai, Vien, Lee, Vivian, Dodge, Karen, Truong, Tran, Wong, Mark, Johnson, Lisa D., Linderoth, Emma, Pang, Xinli, Winston, Jeff, Petrova, Penka S., Uger, Robert A., Viller, Natasja N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662218/
https://ncbi.nlm.nih.gov/pubmed/29084248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187262
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados