Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas

Antibodies that bind CD47 on tumor cells and prevent interaction with SIRPα on phagocytes are active against multiple cancer types including T-cell lymphoma (TCL). Here we demonstrate that surface CD47 is heterogeneously expressed across primary TCLs, whereas major histocompatibility complex (MHC) c...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Jain, Salvia, Van Scoyk, Alexandria, Morgan, Elizabeth A., Matthews, Andrew, Stevenson, Kristen, Newton, Gail, Powers, Foster, Autio, Anu, Louissaint, Abner, Pontini, Guillemette, Aster, Jon C., Luscinskas, Francis W., Weinstock, David M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2019
Konular:
Lymphoid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839960/
https://ncbi.nlm.nih.gov/pubmed/31383641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001744
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