Targeted inhibition of CD47-SIRPα requires Fc-FcγR interactions to maximize activity in T-cell lymphomas

Antibodies that bind CD47 on tumor cells and prevent interaction with SIRPα on phagocytes are active against multiple cancer types including T-cell lymphoma (TCL). Here we demonstrate that surface CD47 is heterogeneously expressed across primary TCLs, whereas major histocompatibility complex (MHC) c...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Jain, Salvia, Van Scoyk, Alexandria, Morgan, Elizabeth A., Matthews, Andrew, Stevenson, Kristen, Newton, Gail, Powers, Foster, Autio, Anu, Louissaint, Abner, Pontini, Guillemette, Aster, Jon C., Luscinskas, Francis W., Weinstock, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839960/
https://ncbi.nlm.nih.gov/pubmed/31383641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001744
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