Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The role of APP

Overexpression of the amyloid precursor protein (APP)gene on chromosome 21 in Down syndrome (DS) has been linked to increased brain amyloid levels and early-onset Alzheimer’s disease (AD). An elderly man with phenotypic DS and partial trisomy of chromosome 21 (PT21) lacked triplication of APP afford...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Doran, Eric, Keator, David, Head, Elizabeth, Phelan, Michael J., Kim, Ron, Totoiu, Minodora, Barrio, Jorge R., Small, Gary W., Potkin, Steven G., Lott, Ira T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662115/
https://ncbi.nlm.nih.gov/pubmed/27983553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160836
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