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Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer’s Disease: The role of APP
Overexpression of the amyloid precursor protein (APP)gene on chromosome 21 in Down syndrome (DS) has been linked to increased brain amyloid levels and early-onset Alzheimer’s disease (AD). An elderly man with phenotypic DS and partial trisomy of chromosome 21 (PT21) lacked triplication of APP afford...
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| Veröffentlicht in: | J Alzheimers Dis |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5662115/ https://ncbi.nlm.nih.gov/pubmed/27983553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160836 |
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