The E3 ubiquitin ligase SCF(Cyclin F) transmits AKT signaling to the cell cycle machinery

The oncogenic AKT kinase is a key regulator of apoptosis, cell growth and cell cycle progression. Despite its important role in proliferation, it remains largely unknown how AKT is mechanistically linked to cell cycle. We show here that Cyclin F, a substrate receptor F-box protein for the SCF family...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Choudhury, Rajarshi, Bonacci, Thomas, Wang, Xianxi, Truong, Andrew, Arceci, Anthony, Zhang, Yanqiong, Mills, Christine A, Kernan, Jennifer L, Liu, Pengda, Emanuele, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662023/
https://ncbi.nlm.nih.gov/pubmed/28954236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.099
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