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Development and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hydroxymidazolam and 4-hydroxymidazolam in pediatric plasma: Application to Pediatric Pharmacokinetic Study

Pharmacokinetic, pharmacodynamic and pharmacogenomic studies of midazolam are currently being performed in critically ill children to find suitable dose regimens. Sensitive assays using small volumes of plasma are necessary to determine the concentrations of midazolam and its respective metabolites...

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Detalles Bibliográficos
Publicado en:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Moorthy, Ganesh S., Jogiraju, Harini, Vedar, Christina, Zuppa, Athena F.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662017/
https://ncbi.nlm.nih.gov/pubmed/28978489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2017.09.030
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