Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disr...

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Bibliografiske detaljer
Udgivet i:Neurobiol Sleep Circadian Rhythms
Main Authors: Dissel, Stephane, Klose, Markus, Donlea, Jeff, Cao, Lijuan, English, Denis, Winsky-Sommerer, Raphaelle, van Swinderen, Bruno, Shaw, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662006/
https://ncbi.nlm.nih.gov/pubmed/29094110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbscr.2016.09.001
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