Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disr...

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Bibliografische gegevens
Gepubliceerd in:Neurobiol Sleep Circadian Rhythms
Hoofdauteurs: Dissel, Stephane, Klose, Markus, Donlea, Jeff, Cao, Lijuan, English, Denis, Winsky-Sommerer, Raphaelle, van Swinderen, Bruno, Shaw, Paul J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662006/
https://ncbi.nlm.nih.gov/pubmed/29094110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbscr.2016.09.001
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