Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiquitous expression of APP:BACE or human tau disr...

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Bibliographic Details
Published in:Neurobiol Sleep Circadian Rhythms
Main Authors: Dissel, Stephane, Klose, Markus, Donlea, Jeff, Cao, Lijuan, English, Denis, Winsky-Sommerer, Raphaelle, van Swinderen, Bruno, Shaw, Paul J.
Format: Artigo
Language:Inglês
Published: Elsevier 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662006/
https://ncbi.nlm.nih.gov/pubmed/29094110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbscr.2016.09.001
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