A global interaction network maps a wiring diagram of cellular function

We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing over 23 million double mutants, identifying ~550,000 negative and ~350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential...

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Publicado en:Science
Main Authors: Costanzo, Michael, VanderSluis, Benjamin, Koch, Elizabeth N., Baryshnikova, Anastasia, Pons, Carles, Tan, Guihong, Wang, Wen, Usaj, Matej, Hanchard, Julia, Lee, Susan D., Pelechano, Vicent, Styles, Erin B., Billmann, Maximilian, van Leeuwen, Jolanda, van Dyk, Nydia, Lin, Zhen-Yuan, Kuzmin, Elena, Nelson, Justin, Piotrowski, Jeff S., Srikumar, Tharan, Bahr, Sondra, Chen, Yiqun, Deshpande, Raamesh, Kurat, Christoph F., Li, Sheena C., Li, Zhijian, Usaj, Mojca Mattiazzi, Okada, Hiroki, Pascoe, Natasha, Luis, Bryan-Joseph San, Sharifpoor, Sara, Shuteriqi, Emira, Simpkins, Scott W., Snider, Jamie, Suresh, Harsha Garadi, Tan, Yizhao, Zhu, Hongwei, Malod-Dognin, Noel, Janjic, Vuk, Przulj, Natasa, Troyanskaya, Olga G., Stagljar, Igor, Xia, Tian, Ohya, Yoshikazu, Gingras, Anne-Claude, Raught, Brian, Boutros, Michael, Steinmetz, Lars M., Moore, Claire L., Rosebrock, Adam P., Caudy, Amy A., Myers, Chad L., Andrews, Brenda, Boone, Charles
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661885/
https://ncbi.nlm.nih.gov/pubmed/27708008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf1420
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