A global interaction network maps a wiring diagram of cellular function

We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing over 23 million double mutants, identifying ~550,000 negative and ~350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential...

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出版年:Science
主要な著者: Costanzo, Michael, VanderSluis, Benjamin, Koch, Elizabeth N., Baryshnikova, Anastasia, Pons, Carles, Tan, Guihong, Wang, Wen, Usaj, Matej, Hanchard, Julia, Lee, Susan D., Pelechano, Vicent, Styles, Erin B., Billmann, Maximilian, van Leeuwen, Jolanda, van Dyk, Nydia, Lin, Zhen-Yuan, Kuzmin, Elena, Nelson, Justin, Piotrowski, Jeff S., Srikumar, Tharan, Bahr, Sondra, Chen, Yiqun, Deshpande, Raamesh, Kurat, Christoph F., Li, Sheena C., Li, Zhijian, Usaj, Mojca Mattiazzi, Okada, Hiroki, Pascoe, Natasha, Luis, Bryan-Joseph San, Sharifpoor, Sara, Shuteriqi, Emira, Simpkins, Scott W., Snider, Jamie, Suresh, Harsha Garadi, Tan, Yizhao, Zhu, Hongwei, Malod-Dognin, Noel, Janjic, Vuk, Przulj, Natasa, Troyanskaya, Olga G., Stagljar, Igor, Xia, Tian, Ohya, Yoshikazu, Gingras, Anne-Claude, Raught, Brian, Boutros, Michael, Steinmetz, Lars M., Moore, Claire L., Rosebrock, Adam P., Caudy, Amy A., Myers, Chad L., Andrews, Brenda, Boone, Charles
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661885/
https://ncbi.nlm.nih.gov/pubmed/27708008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf1420
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