A global interaction network maps a wiring diagram of cellular function

We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing over 23 million double mutants, identifying ~550,000 negative and ~350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Costanzo, Michael, VanderSluis, Benjamin, Koch, Elizabeth N., Baryshnikova, Anastasia, Pons, Carles, Tan, Guihong, Wang, Wen, Usaj, Matej, Hanchard, Julia, Lee, Susan D., Pelechano, Vicent, Styles, Erin B., Billmann, Maximilian, van Leeuwen, Jolanda, van Dyk, Nydia, Lin, Zhen-Yuan, Kuzmin, Elena, Nelson, Justin, Piotrowski, Jeff S., Srikumar, Tharan, Bahr, Sondra, Chen, Yiqun, Deshpande, Raamesh, Kurat, Christoph F., Li, Sheena C., Li, Zhijian, Usaj, Mojca Mattiazzi, Okada, Hiroki, Pascoe, Natasha, Luis, Bryan-Joseph San, Sharifpoor, Sara, Shuteriqi, Emira, Simpkins, Scott W., Snider, Jamie, Suresh, Harsha Garadi, Tan, Yizhao, Zhu, Hongwei, Malod-Dognin, Noel, Janjic, Vuk, Przulj, Natasa, Troyanskaya, Olga G., Stagljar, Igor, Xia, Tian, Ohya, Yoshikazu, Gingras, Anne-Claude, Raught, Brian, Boutros, Michael, Steinmetz, Lars M., Moore, Claire L., Rosebrock, Adam P., Caudy, Amy A., Myers, Chad L., Andrews, Brenda, Boone, Charles
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661885/
https://ncbi.nlm.nih.gov/pubmed/27708008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf1420
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