Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson’s substantia nigra

Iron deposition in Parkinson’s disease (PD) is a potential disease-modifying target. We previously showed that supplementation of the iron-exporter, ceruloplasmin, selectively corrected nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model. Ceruloplasmin delivers iro...

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Vydáno v:Signal Transduct Target Ther
Hlavní autoři: Ayton, Scott, Lei, Peng, Mclean, Catriona, Bush, Ashley I, Finkelstein, David I
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661661/
https://ncbi.nlm.nih.gov/pubmed/29263898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2016.15
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