Lyn prevents aberrant inflammatory responses to Pseudomonas infection in mammalian systems by repressing a SHIP-1-associated signaling cluster

The pleiotropic Src kinase Lyn has critical roles in host defense in alveolar macrophages against bacterial infection, but the underlying mechanism for Lyn-mediated inflammatory response remains largely elusive. Using mouse Pseudomonas aeruginosa infection models, we observed that Lyn(−/−) mice mani...

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Vydáno v:Signal Transduct Target Ther
Hlavní autoři: Li, Rongpeng, Fang, Lizhu, Pu, Qinqin, Lin, Ping, Hoggarth, Austin, Huang, Huang, Li, Xuefeng, Li, Guoping, Wu, Min
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661651/
https://ncbi.nlm.nih.gov/pubmed/29263906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2016.32
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