A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity

Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation. A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as program death-1 (PD-1/PD-L1) pathway in the tumor environm...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Tian, Hongwei, Shi, Gang, Wang, Qin, Li, Yiming, Yang, Qianmei, Li, Chunlei, Yang, Guoyou, Wu, Min, Xie, Qian, Zhang, Shuang, Yang, Yang, Xiang, Rong, Yu, Dechao, Wei, Yuquan, Deng, Hongxin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661645/
https://ncbi.nlm.nih.gov/pubmed/29263903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2016.25
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