Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

BACKGROUND: Although the whole tumor cell vaccine can provide the best source of immunizing antigens, there is still a limitation that most tumors are not naturally immunogenic. Tumor cells genetically modified to secrete immune activating cytokines have been proved to be more immunogenic. IL-18 cou...

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Main Authors: Tian, Hongwei, Shi, Gang, Yang, Guoyou, Zhang, Junfeng, Li, Yiming, Du, Tao, Wang, Jianzhou, Xu, Fen, Cheng, Lin, Zhang, Xiaomei, Dai, Lei, Chen, Xiaolei, Zhang, Shuang, Yang, Yang, Yu, Dechao, Wei, Yuquan, Deng, Hongxin
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922726/
https://ncbi.nlm.nih.gov/pubmed/24475975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-48
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