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Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression

Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated the significant inhibitory effects of a novel chemically synthetic peptide (E5) on the CXCR4/...

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Détails bibliographiques
Publié dans:Signal Transduct Target Ther
Auteurs principaux: Guo, Hua, Ge, Yangyang, Li, Xiaojin, Yang, Yanlian, Meng, Jie, Liu, Jian, Wang, Chen, Xu, Haiyan
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661635/
https://ncbi.nlm.nih.gov/pubmed/29263923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2017.33
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