Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists

BACKGROUND: The CXCL12-CXCR4 signaling axis in malignant tumor biology has increased in importance, and these peptides are implicated in tumor growth, invasion and metastasis. The aim of our study was to examine the important role of the axis in pancreatic cancer (PaCa) cells’ relationship with stro...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Morimoto, Mamoru, Matsuo, Yoichi, Koide, Shuji, Tsuboi, Ken, Shamoto, Tomoya, Sato, Takafumi, Saito, Kenta, Takahashi, Hiroki, Takeyama, Hiromitsu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866076/
https://ncbi.nlm.nih.gov/pubmed/27175473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2340-z
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