Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists

BACKGROUND: The CXCL12-CXCR4 signaling axis in malignant tumor biology has increased in importance, and these peptides are implicated in tumor growth, invasion and metastasis. The aim of our study was to examine the important role of the axis in pancreatic cancer (PaCa) cells’ relationship with stro...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Morimoto, Mamoru, Matsuo, Yoichi, Koide, Shuji, Tsuboi, Ken, Shamoto, Tomoya, Sato, Takafumi, Saito, Kenta, Takahashi, Hiroki, Takeyama, Hiromitsu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866076/
https://ncbi.nlm.nih.gov/pubmed/27175473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2340-z
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