Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists

BACKGROUND: The CXCL12-CXCR4 signaling axis in malignant tumor biology has increased in importance, and these peptides are implicated in tumor growth, invasion and metastasis. The aim of our study was to examine the important role of the axis in pancreatic cancer (PaCa) cells’ relationship with stro...

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Publicado en:BMC Cancer
Autores principales: Morimoto, Mamoru, Matsuo, Yoichi, Koide, Shuji, Tsuboi, Ken, Shamoto, Tomoya, Sato, Takafumi, Saito, Kenta, Takahashi, Hiroki, Takeyama, Hiromitsu
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866076/
https://ncbi.nlm.nih.gov/pubmed/27175473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2340-z
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