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A designed peptide targeting CXCR4 displays anti-acute myelocytic leukemia activity in vitro and in vivo
Leukemia cells highly expressing chemokine receptor CXCR4 can actively response to stroma derived factor 1α (CXCL12), trafficking and homing to the marrow microenvironment, which causes poor prognosis and relapse. Here we demonstrate that a novel designed peptide (E5) targeting CXCR4 inhibits CXCL12...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4196105/ https://ncbi.nlm.nih.gov/pubmed/25312253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06610 |
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