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Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation
The underlying anticancer effects of butyrate, an end-product of the intestinal microbial fermentation of dietary fiber, remain elusive. Here, we report that butyrate promotes cancer cell apoptosis by acting as a SIRT3 inhibitor. Butyrate inhibits SIRT3 both in cultured cells and in vitro. Butyrate-...
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| Publicado no: | Signal Transduct Target Ther |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5661613/ https://ncbi.nlm.nih.gov/pubmed/29263907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2016.35 |
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