The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation

The biosynthesis of the major acyl carrier Coenzyme A from pantothenic acid (PA) is critical for survival of Plasmodium falciparum within human erythrocytes. Accordingly, a PA analog α-PanAm showed potent activity against blood stage parasites in vitro; however, its efficacy in vivo and its mode of...

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Publicat a:Sci Rep
Autors principals: Chiu, Joy E., Thekkiniath, Jose, Choi, Jae-Yeon, Perrin, Benjamin A., Lawres, Lauren, Plummer, Mark, Virji, Azan Z., Abraham, Amanah, Toh, Justin Y., Zandt, Michael Van, Aly, Ahmed S. I., Voelker, Dennis R., Mamoun, Choukri Ben
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660193/
https://ncbi.nlm.nih.gov/pubmed/29079738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14074-9
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