The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD–PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan)

[Image: see text] The antimetabolite pentyl pantothenamide has broad spectrum antibiotic activity but exhibits enhanced activity against Escherichia coli. The PanDZ complex has been proposed to regulate the pantothenate biosynthetic pathway in E. coli by limiting the supply of β-alanine in response...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Arnott, Zoe L. P., Nozaki, Shingo, Monteiro, Diana C. F., Morgan, Holly E., Pearson, Arwen R., Niki, Hironori, Webb, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724930/
https://ncbi.nlm.nih.gov/pubmed/28832133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00509
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