Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

Pulmonary fibrosis is characterized by fibroblast proliferation and extracellular matrix remodelling, leading to respiratory insufficiency. The mechanisms underlying this progressive and devastating disease remain unclear. Conditions that can impair the function of the endoplasmic reticulum (ER) cau...

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Pubblicato in:Sci Rep
Autori principali: Hsu, Han-Shui, Liu, Chen-Chi, Lin, Jiun-Han, Hsu, Tien-Wei, Hsu, Jyuan-Wei, Su, Kelly, Hung, Shih-Chieh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660192/
https://ncbi.nlm.nih.gov/pubmed/29079731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14612-5
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