Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

Pulmonary fibrosis is characterized by fibroblast proliferation and extracellular matrix remodelling, leading to respiratory insufficiency. The mechanisms underlying this progressive and devastating disease remain unclear. Conditions that can impair the function of the endoplasmic reticulum (ER) cau...

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Vydáno v:Sci Rep
Hlavní autoři: Hsu, Han-Shui, Liu, Chen-Chi, Lin, Jiun-Han, Hsu, Tien-Wei, Hsu, Jyuan-Wei, Su, Kelly, Hung, Shih-Chieh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660192/
https://ncbi.nlm.nih.gov/pubmed/29079731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14612-5
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