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Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

Pulmonary fibrosis is characterized by fibroblast proliferation and extracellular matrix remodelling, leading to respiratory insufficiency. The mechanisms underlying this progressive and devastating disease remain unclear. Conditions that can impair the function of the endoplasmic reticulum (ER) cau...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Hsu, Han-Shui, Liu, Chen-Chi, Lin, Jiun-Han, Hsu, Tien-Wei, Hsu, Jyuan-Wei, Su, Kelly, Hung, Shih-Chieh
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660192/
https://ncbi.nlm.nih.gov/pubmed/29079731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14612-5
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