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Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

Pulmonary fibrosis is characterized by fibroblast proliferation and extracellular matrix remodelling, leading to respiratory insufficiency. The mechanisms underlying this progressive and devastating disease remain unclear. Conditions that can impair the function of the endoplasmic reticulum (ER) cau...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hsu, Han-Shui, Liu, Chen-Chi, Lin, Jiun-Han, Hsu, Tien-Wei, Hsu, Jyuan-Wei, Su, Kelly, Hung, Shih-Chieh
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660192/
https://ncbi.nlm.nih.gov/pubmed/29079731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14612-5
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