Patient-derived xenografts undergo murine-specific tumor evolution

Patient-derived xenografts (PDXs) have become a prominent cancer model system, as they are presumed to faithfully represent the genomic features of primary tumors. Here we monitored the dynamics of copy number alterations (CNAs) in 1,110 PDX samples across 24 cancer types. We observed rapid accumula...

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Библиографические подробности
Опубликовано в: :Nat Genet
Главные авторы: Ben-David, Uri, Ha, Gavin, Tseng, Yuen-Yi, Greenwald, Noah F., Oh, Coyin, Shih, Juliann, McFarland, James M., Wong, Bang, Boehm, Jesse S., Beroukhim, Rameen, Golub, Todd R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659952/
https://ncbi.nlm.nih.gov/pubmed/28991255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3967
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