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GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle

The GATOR1/SEACIT complex consisting of Iml1-Npr2-Npr3 inhibits Target of Rapamycin Complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, Saccharomyces cerevisiae mutants lacking the function of this complex grow poorly in the absence of amino acid supplementation, despite ha...

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Bibliografiske detaljer
Udgivet i:Nat Chem Biol
Main Authors: Chen, Jun, Sutter, Benjamin M., Shi, Lei, Tu, Benjamin P.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659745/
https://ncbi.nlm.nih.gov/pubmed/28920930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2478
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