DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin

Gene regulatory programs are encoded in the sequence of the DNA. Since the completion of the Human Genome Project, millions of gene regulatory elements have been identified in the human genome. Understanding how each of those sites functionally contributes to gene regulation, however, remains a chal...

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Pubblicato in:Endocrinology
Autori principali: Coons, Laurel A., Hewitt, Sylvia C., Burkholder, Adam B., McDonnell, Donald P., Korach, Kenneth S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2017
Soggetti:
Special Section: Targeting and Regulation of Hormone Signaling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659708/
https://ncbi.nlm.nih.gov/pubmed/28977594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00468
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