DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin

Gene regulatory programs are encoded in the sequence of the DNA. Since the completion of the Human Genome Project, millions of gene regulatory elements have been identified in the human genome. Understanding how each of those sites functionally contributes to gene regulation, however, remains a chal...

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Publicat a:Endocrinology
Autors principals: Coons, Laurel A., Hewitt, Sylvia C., Burkholder, Adam B., McDonnell, Donald P., Korach, Kenneth S.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2017
Matèries:
Special Section: Targeting and Regulation of Hormone Signaling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659708/
https://ncbi.nlm.nih.gov/pubmed/28977594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00468
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