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Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice

Sirtuin-3 (Sirt3) is an essential metabolic regulatory enzyme that plays an important role in mitochondrial metabolism, but its role in bone marrow and skeletal homeostasis remains largely unknown. In this study, we hypothesize that increased expression of Sirt3 plays a role in skeletal aging. Using...

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Bibliografske podrobnosti
izdano v:Endocrinology
Main Authors: Ho, Linh, Wang, Liping, Roth, Theresa M., Pan, Yong, Verdin, Eric M., Hsiao, Edward C., Nissenson, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659662/
https://ncbi.nlm.nih.gov/pubmed/28911171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1739
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