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Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice

Sirtuin-3 (Sirt3) is an essential metabolic regulatory enzyme that plays an important role in mitochondrial metabolism, but its role in bone marrow and skeletal homeostasis remains largely unknown. In this study, we hypothesize that increased expression of Sirt3 plays a role in skeletal aging. Using...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Ho, Linh, Wang, Liping, Roth, Theresa M., Pan, Yong, Verdin, Eric M., Hsiao, Edward C., Nissenson, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659662/
https://ncbi.nlm.nih.gov/pubmed/28911171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1739
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