Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis

The identification of the TAR DNA-binding protein 43 (TDP-43) as the ubiquitinated cytoplasmic inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) confirmed that these two diseases share similar mechanisms, likely to be linked to the abnormal hyperphosphory...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Tan, Rachel H., Yang, Yue, Kim, Woojin S., Dobson-Stone, Carol, Kwok, John B., Kiernan, Matthew C., Halliday, Glenda M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658959/
https://ncbi.nlm.nih.gov/pubmed/29078806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0480-2
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