Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

Transactivation response DNA binding protein 43 kDa (TDP-43) is known to be a pathologic protein in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 is normally a nuclear protein, but affected neurons of ALS or FTLD patients exhibit mislocalization of nuclear...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Riku, Yuichi, Seilhean, Danielle, Duyckaerts, Charles, Boluda, Susana, Iguchi, Yohei, Ishigaki, Shinsuke, Iwasaki, Yasushi, Yoshida, Mari, Sobue, Gen, Katsuno, Masahisa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068029/
https://ncbi.nlm.nih.gov/pubmed/33917673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22083843
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