TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration

The G4C2 hexanucleotide repeat expansion mutation in the C9orf72 gene is the most common genetic cause underlying both amyotrophic lateral sclerosis and frontotemporal dementia. Pathologically, these two neurodegenerative disorders are linked by the common presence of abnormal phosphorylated TDP-43...

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Publicado en:Brain Commun
Autores principales: Lee, Samuel M, Asress, Seneshaw, Hales, Chadwick M, Gearing, Marla, Vizcarra, Juan C, Fournier, Christina N, Gutman, David A, Chin, Lih-Shen, Li, Lian, Glass, Jonathan D
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788139/
https://ncbi.nlm.nih.gov/pubmed/31633109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcz014
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