Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents

The selective reaction of chemical reagents with reduced protein thiols is critical to biological research. This reaction is utilized to prevent cross-linking of cysteine-containing peptides in common proteomics workflows and is applied widely in discovery and targeted redox investigations of the me...

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Udgivet i:ACS Chem Biol
Main Authors: Chen, Xiaofei, Wu, Hanzhi, Park, Chung-Min, Poole, Thomas H., Keceli, Gizem, Devarie-Baez, Nelmi O., Tsang, Allen W., Lowther, W. Todd, Poole, Leslie B., King, S. Bruce, Xian, Ming, Furdui, Cristina M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658784/
https://ncbi.nlm.nih.gov/pubmed/28687042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00444
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