De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 leads to a metabolic reprogramming associated with gene networks orchestrate...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mol Syst Biol
Hlavní autoři: Tarrado‐Castellarnau, Míriam, de Atauri, Pedro, Tarragó‐Celada, Josep, Perarnau, Jordi, Yuneva, Mariia, Thomson, Timothy M, Cascante, Marta
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658703/
https://ncbi.nlm.nih.gov/pubmed/28978620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20167321
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky