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De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition
Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 leads to a metabolic reprogramming associated with gene networks orchestrate...
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| Publicado no: | Mol Syst Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5658703/ https://ncbi.nlm.nih.gov/pubmed/28978620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20167321 |
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