Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes

With very similar 3D structures, the widely expressed β-arrestin isoforms 1 and 2 play at times identical, distinct or even opposing roles in regulating various aspects of G protein-coupled receptors (GPCR) expression and signalling. Recent evidence recognizes the β-arrestin system as a key regulato...

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Publicat a:Oncogene
Autors principals: Suleymanova, N, Crudden, C, Shibano, T, Worrall, C, Oprea, I, Tica, A, Calin, G A, Girnita, A, Girnita, L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658667/
https://ncbi.nlm.nih.gov/pubmed/28581517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.179
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