Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma

Melanoma tumors usually retain wild-type p53; however, its tumor-suppressor activity is functionally disabled, most commonly through an inactivating interaction with mouse double-minute 2 homolog (Mdm2), indicating p53 release from this complex as a potential therapeutic approach. P53 and the tumor-...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Worrall, C, Suleymanova, N, Crudden, C, Trocoli Drakensjö, I, Candrea, E, Nedelcu, D, Takahashi, S-I, Girnita, L, Girnita, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474566/
https://ncbi.nlm.nih.gov/pubmed/28092675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.472
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