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Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and catalyzes membrane fission (Schmid and Frolov, 2011; Ferguson and De Camilli, 2012). Dynamin fission reaction is strictly dependent on GTP hydrolysis, but how fission is mediated is still debated (Antonny et al....

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Galli, Valentina, Sebastian, Rafael, Moutel, Sandrine, Ecard, Jason, Perez, Franck, Roux, Aurélien
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658065/
https://ncbi.nlm.nih.gov/pubmed/29022874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25197
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