Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

PURPOSE: Interleukin-10 (IL-10) stimulates the expansion and cytotoxicity of tumor-infiltrating CD8+ T cells and inhibits inflammatory CD4+ T cells. Pegylation prolongs the serum concentration of IL-10 without changing the immunologic profile. This phase I study sought to determine the safety and an...

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Dades bibliogràfiques
Publicat a:J Clin Oncol
Autors principals: Naing, Aung, Papadopoulos, Kyriakos P., Autio, Karen A., Ott, Patrick A., Patel, Manish R., Wong, Deborah J., Falchook, Gerald S., Pant, Shubham, Whiteside, Melinda, Rasco, Drew R., Mumm, John B., Chan, Ivan H., Bendell, Johanna C., Bauer, Todd M., Colen, Rivka R., Hong, David S., Van Vlasselaer, Peter, Tannir, Nizar M., Oft, Martin, Infante, Jeffrey R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2016
Matèries:
Original Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657013/
https://ncbi.nlm.nih.gov/pubmed/27528724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.68.1106
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