Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

PURPOSE: Interleukin-10 (IL-10) stimulates the expansion and cytotoxicity of tumor-infiltrating CD8+ T cells and inhibits inflammatory CD4+ T cells. Pegylation prolongs the serum concentration of IL-10 without changing the immunologic profile. This phase I study sought to determine the safety and an...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Naing, Aung, Papadopoulos, Kyriakos P., Autio, Karen A., Ott, Patrick A., Patel, Manish R., Wong, Deborah J., Falchook, Gerald S., Pant, Shubham, Whiteside, Melinda, Rasco, Drew R., Mumm, John B., Chan, Ivan H., Bendell, Johanna C., Bauer, Todd M., Colen, Rivka R., Hong, David S., Van Vlasselaer, Peter, Tannir, Nizar M., Oft, Martin, Infante, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2016
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657013/
https://ncbi.nlm.nih.gov/pubmed/27528724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.68.1106
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