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Release of Enzymatically Active Deubiquitinating Enzymes upon Reversible Capture by Disulfide Ubiquitin Reagents

Deubiquitinating enzymes (DUBs) catalyze the cleavage of ubiquitin from target proteins. Ubiquitin is post‐translationally attached to proteins and serves as an important regulatory signal for key cellular processes. In this study, novel activity‐based probes to study DUBs were synthesized that comp...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: de Jong, Annemieke, Witting, Katharina, Kooij, Raymond, Flierman, Dennis, Ovaa, Huib
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656918/
https://ncbi.nlm.nih.gov/pubmed/28841265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706738
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