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Release of Enzymatically Active Deubiquitinating Enzymes upon Reversible Capture by Disulfide Ubiquitin Reagents

Deubiquitinating enzymes (DUBs) catalyze the cleavage of ubiquitin from target proteins. Ubiquitin is post‐translationally attached to proteins and serves as an important regulatory signal for key cellular processes. In this study, novel activity‐based probes to study DUBs were synthesized that comp...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: de Jong, Annemieke, Witting, Katharina, Kooij, Raymond, Flierman, Dennis, Ovaa, Huib
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656918/
https://ncbi.nlm.nih.gov/pubmed/28841265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706738
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