Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles

Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosphate (PI4P), is only partially underst...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Melia, Charlotte E., van der Schaar, Hilde M., Lyoo, Heyrhyoung, Limpens, Ronald W.A.L., Feng, Qian, Wahedi, Maryam, Overheul, Gijs J., van Rij, Ronald P., Snijder, Eric J., Koster, Abraham J., Bárcena, Montserrat, van Kuppeveld, Frank J.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Authors. 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656745/
https://ncbi.nlm.nih.gov/pubmed/29045829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.068
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