Evaluation of Ga-DOTA-(D-Asp)(n) as bone imaging agents: D-aspartic acid peptides as carriers to bone

(67)Ga-DOTA-(L-Asp)(11) and (67)Ga-DOTA-(L-Asp)(14), which have been developed as bone imaging agents, showed a high accumulation in bone and a rapid blood clearance in mice. However, peptides composed of D-amino acids are more stable in vivo than those composed of their L-equivalents. In this study...

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Publicado no:Sci Rep
Main Authors: Ogawa, Kazuma, Ishizaki, Atsushi, Takai, Kenichiro, Kitamura, Yoji, Makino, Akira, Kozaka, Takashi, Kiyono, Yasushi, Shiba, Kazuhiro, Odani, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656653/
https://ncbi.nlm.nih.gov/pubmed/29070853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14149-7
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