A Radiobrominated Tyrosine Kinase Inhibitor for EGFR with L858R/T790M Mutations in Lung Carcinoma

Activating double mutations L858R/T790M in the epidermal growth factor receptor (EGFR) region are often observed as the cause of resistance to tyrosine kinase inhibitors (TKIs). Third-generation EGFR-TKIs, such as osimertinib and rociletinib (CO-1686), was developed to target such resistance mutatio...

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Bibliographische Detailangaben
Veröffentlicht in:Pharmaceuticals (Basel)
Hauptverfasser: Fawwaz, Muammar, Mishiro, Kenji, Nishii, Ryuichi, Makino, Akira, Kiyono, Yasushi, Shiba, Kazuhiro, Kinuya, Seigo, Ogawa, Kazuma
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998589/
https://ncbi.nlm.nih.gov/pubmed/33809064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14030256
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