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Selective sp(3) C–H alkylation via polarity-match-based cross-coupling

The functionalization of carbon–hydrogen (C–H) bonds is one of the most attractive strategies for molecular construction in organic chemistry. The hydrogen atom is considered to be an ideal coupling handle, owing to its relative abundance in organic molecules and its availability for functionalizati...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Le, Chip, Liang, Yufan, Evans, Ryan W., Li, Ximing, MacMillan, David W. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655994/
https://ncbi.nlm.nih.gov/pubmed/28636596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22813
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