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Enantiomeric barbiturates bind distinct inter- and intrasubunit binding sites in a nicotinic acetylcholine receptor (nAChR)
Nicotinic acetylcholine receptors (nAChRs) and γ-aminobutyric acid type A receptors (GABA(A)Rs) are members of the pentameric ligand-gated ion channel superfamily. Drugs acting as positive allosteric modulators of muscle-type α(2)βγδ nAChRs, of use in treatment of neuromuscular disorders, have been...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5655505/ https://ncbi.nlm.nih.gov/pubmed/28878016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808592 |
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