Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae

Vaborbactam (formerly RPX7009) is a new beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore. The spectrum of beta-lactamase inhibition by vaborbactam and the impact of bacterial efflux and permeability on its activity were determined using a panel of strains with beta-lactamases cl...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Lomovskaya, Olga, Sun, Dongxu, Rubio-Aparicio, Debora, Nelson, Kirk, Tsivkovski, Ruslan, Griffith, David C., Dudley, Michael N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655098/
https://ncbi.nlm.nih.gov/pubmed/28848018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01443-17
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