Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae

Vaborbactam (formerly RPX7009) is a new beta-lactamase inhibitor based on a cyclic boronic acid pharmacophore. The spectrum of beta-lactamase inhibition by vaborbactam and the impact of bacterial efflux and permeability on its activity were determined using a panel of strains with beta-lactamases cl...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Lomovskaya, Olga, Sun, Dongxu, Rubio-Aparicio, Debora, Nelson, Kirk, Tsivkovski, Ruslan, Griffith, David C., Dudley, Michael N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655098/
https://ncbi.nlm.nih.gov/pubmed/28848018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01443-17
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