Phosphoinositide-specific phospholipase Cγ1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells

Phosphoinositide-specific phospholipase C (PLC) γ1 has been reported to be involved in cancer cell proliferation and metastasis. However, whether PLCγ1 modulates autophagy and the underlying mechanism remains unclear. Here, we investigated the relationship between PLCγ1 and autophagy in the human co...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Dai, Lianzhi, Chen, Xiaolei, Lu, Xiaohong, Wang, Fen, Zhan, Yanyan, Song, Gang, Hu, Tianhui, Xia, Chun, Zhang, Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654964/
https://ncbi.nlm.nih.gov/pubmed/29066806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13334-y
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